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The 2009 Neuroscience Retreat was held at the Student life Center. To view some of the pictures taken at the retreat, you must enter the SLC by clicking on the above picture.

 

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Mark T. Wallace, Ph.D.

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Muglia
"We are over 300 scientists from 50 departments, centers, and institutes across the Vanderbilt campus delving into questions in brain sciences spanning a spectrum from molecules to the mind."

 

 

 

Introduction to The Louis J. Muglia, Featured Article

The amygdala is a key limbic area involved in fear responses and pavlovian conditioning with the potential to directly respond to endocrine signals associated with fear or stress. To gain insights into the molecular mechanisms and subregional specificity of fear conditioning, we disrupted type II glucocorticoid receptors (GRs) in the
central nucleus of the amygdala (CeA) by delivering lentiviral vectors containing Cre-recombinase into floxed-GR mice. GR deletion in the CeA (CeAGRKO mice) prevented conditioned fear behavior. In contrast, forebrain disruption of GRs excluding the CeA did not. The conditioned fear deficit in CeAGRKO mice was associated with decreases in cFos and corticotropin-releasing hormone (CRH) expression. Moreover, intracerebroventricular delivery of CRH rescued the conditioned fear deficit in CeAGRKO mice. We conclude that fear conditioning
involves a neuroendocrine circuit by using GR activation in the CeA for acute CRH induction and long-lasting behavioral modulation.

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This page was last updated June 2, 2009 and is maintained by Steve Edminster